Has the epidemic of allergic contact dermatitis due to methylisothiazolinone reached its peak?

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Update on allergic contact dermatitis due to methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone.

The combination of methylchloroisothiazolinone (MCI) and methylisothiazolinone (MI) is widely used as a preservative in cosmetics, household, and industrial products. Furthermore, MI at a concentration of 100 ppm has been permitted in cosmetic products since 2005. Recently, a considerable increase in cases of contact dermatitis to both MCI and MI have been noted, and this warrants closer monito...

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Methylisothiazolinone (MI) is a preservative found in cosmetic and industrial products. Contact dermatitis caused by either methylchloroisothiazolinone/methylisothiazolinone (MCI/MI or Kathon CG) or MI has shown increasing frequency. The latter is preferably detected through epicutaneous testing with aqueous MI 2000 ppm, which is not included in the Brazilian standard tray. We describe a series...

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MCI: methylchloroisothiazolinone MI: methylisothiazolinone INTRODUCTION Methylisothiazolinone and methylchloroisothiazolinone (MI/MCI) are broad-spectrum preservatives widely used in cosmetics and household and industrial products. It is well known that MI/MCI can cause allergic contact dermatitis with a spongiotic reaction pattern. Because of this reaction, restrictions have been placed on the...

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ژورنال

عنوان ژورنال: British Journal of Dermatology

سال: 2017

ISSN: 0007-0963

DOI: 10.1111/bjd.15016